BIO（GSK-3β inhibitor），糖原合成酶激酶抑制劑，BIO-005/025/100

產品信息

Wnt信號通路是一個復雜的蛋白質作用網絡，其功能zui常見于胚胎發育和癌癥，但也參與成年動物的正常生理過程。Wnt信號通路包括許多可調控Wnt信號分子合成的蛋白質，它們與靶細胞上的受體相互作用，而靶細胞的生理反應則來源于細胞和胞外Wnt配體的相互作用。

BIO (6-bromoindirubin-3'-oxime):
a specific GSK3 kinase inhibitor. Inhibition of GSK3-beta results in activation of the canonical WNT pathway leading to the translocation of beta-catenin to the nucleus.

This chemical compound from StemRD is 98.5% pure (HPLC). In a cell-based assay measuring the activation of the TCF reporter gene, this compound gives EC50 of 5.0 micromolar.

Purity:
Greater than 98.5% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.

Biological Activity:
In a cell-based assay measuring the activation of the TCF reporter gene, this compound gives EC50 of 5.0 micromolar.

重慶市華雅干細胞技術有限公司